Recent Publications

Recent Publications


  1. Kurotsu S, Osakabe R, Isomi M, Tamura F, Sadahiro T, Muraoka N, Kojima H, Haginiwa S, Tani H, Nara K, Kubota Y, Ema M, Fukuda K, Suzuki T, *Ieda M. Distinct expression patterns of Flk1 and Flt1 in the coronary vascular system during development and after myocardial infarction. Biochem Biophys Res Commun [Epub ahead of print] 2017. pubmed
  2. Kim J, Park DY, Bae H, Park DY, Kim D, Lee CK, Song S, Chung TY, Lim DH, Kubota Y, Hong YK, He Y, Augustin HG, Oliver G, *Koh GY. Impaired angiopoietin/Tie2 signaling compromises Schlemm's canal integrity and induces glaucoma. J Clin Invest 127(10): 3877-3896, 2017. pubmed
  3. Kim J, Kim YH, Kim J, Park DY, Bae H, Lee DH, Kim KH, Hong SP, Jang SP, Kubota Y, Kwon YG, Lim DS, *Koh GY. YAP/TAZ regulates sprouting angiogenesis and vascular barrier maturation. J Clin Invest 127(9): 3441-3461, 2017. pubmed
  4. Tai-Nagara I, Yoshikawa Y, Numata N, Ando T, Okabe K, Sugiura Y, Ieda M, Takakura N, Nakagawa O, Zhou B, Okabayashi K, Suematsu M, Kitagawa Y, Bastmeyer M, Sato K, Klein R, Navankasattusas S, Li DY, Yamagishi S, *Kubota Y. Placental labyrinth formation in mice requires endothelial FLRT2–UNC5B signaling. Development 144(13): 2392-2401, 2017 [Epub ahead of print]. pubmed
    Development "In This Issue"
  5. Park DY, Lee J, Kim J, Kim K, Hong S, Han S, Kubota Y, Augustin HG, Ding L, Kim JW, Kim H, He Y, Adams RH, *Koh GY. Plastic roles of pericytes in the blood-retinal barrier. Nat Commun; 8: 15296. doi: 10.1038/ncomms15296. 2017 pubmed
  6. Jang JY, Choi SY, Park I, Park DY, Choe K, Kim P, Kim YK, Lee BJ, Hirashima M, Kubota Y, Park JW, Cheng SY, Nagy A, Park YJ, Alitalo K, Shong M, *Koh GY. VEGFR2 but not VEGFR3 governs integrity and remodeling of thyroid angiofollicular unit in normal state and during goitrogenesis. EMBO Mol Med; 2017 pii: e201607341. doi: 10.15252/emmm.201607341. pubmed
  7. Yamazaki T, Nalbandian A, Uchida Y, Li W, Arnold TD, Kubota Y, Yamamoto S, Ema M, Mukouyama YS. Tissue Myeloid Progenitors Differentiate into Pericytes through TGF-β Signaling in Developing Skin Vasculature. Cell Rep; 18(12): 2991-3004, 2017. pubmed


  1. Yoshikawa Y, Yamada T, Tai-Nagara I, Okabe K, Kitagawa Y, Ema M and *Kubota Y. Developmental regression of hyaloid vasculature is triggered by neurons. J Exp Med 213(7): 1175-83, 2016.pubmed
    Press release (Japanese)
    Newspaper article (Japanese)
  2. Karigane D, Kobayashi H, Morikawa T, Ootomo Y, Sakai M, Nagamatsu G, Kubota Y, Goda N, Matsumoto M, Nishimura EK, Soga T, Otsu K, Suematsu M, Okamoto S, Suda T and *Takubo K. p38α activates purine metabolism to initiate hematopoietic stem/progenitor cell cycling. Cell Stem Cell 19(2):192-204, 2016. pubmed
  3. Ozaki T, *Muramatsu R, Sasai M, Yamamoto M, Kubota Y, Fujinaka T, Yoshimine T and *Yamashita T. The P2X4 receptor is required for neuroprotection via ischemic preconditioning. Sci Rep 6:25893. doi: 10.1038/srep25893, 2016. pubmed
  4. Kim K, Kim IK, Yang JM, Lee E, Koh BI, Song S, Park J, Lee S, Choi C, Kim JW, Kubota Y, Koh GY, *Kim I. SoxF Transcription Factors Are Positive Feedback Regulators of VEGF Signaling. Circ Res 119(7): 839-52. pubmed


  1. *Matsuo K, Kuroda Y, Nango N, Shimoda K, Kubota Y, Ema M, Bakiri L, Wagner EF, Takeda Y, Yashiro W and Momose A. Osteogenic capillaries orchestrate growth plate-independent ossification of the malleus. Development 142(22): 3912-20, 2015. pubmed
  2. Hong KY, Bae H, Park I, Park DY, Kim KH, Kubota Y, Cho ES, Kim H, Adams RH, Yoo OJ, *Koh GY. Perilipin+ embryonic preadipocytes actively proliferate along growing vasculatures for adipose expansion. Development 142(15): 2623-32, 2015. pubmed
  3. Zarkada G, Heinolainen K, Makinen T, Kubota Y and *Alitalo K. VEGFR3 does not sustain retinal angiogenesis without VEGFR2. Proc Natl Acad Sci USA 112(3): 761-6, 2015. pubmed


  1. Tai-Nagara I, *Matsuoka S, Ariga H, *Suda T. Mortalin and DJ-1 coordinately regulate hematopoietic stem cell function through the control of oxidative stress. Blood 123(1): 41-50, 2014. pubmed
  2. *Kubota Y. Unveiling Angptl2, a rising HSC expander. Blood 124(6): 833-834 2014 (invited commentary). pubmed
  3. Okabe K, Kobayashi S, Yamad T, Kurihara T, Tai-Nagara I, Miyamoto T, Mukouyama YS, Sato TN, Suda T, Ema M and *Kubota Y. Neurons limit angiogenesis by titrating VEGF in retina. Cell 159: 584-596 2014. pubmed
    Cell preview
    Science signaling
    Lifescience review (Japanese)
    Scienceportal (Japanese)


  1. Ikushima YM, *Arai F, Nakamra Y, Hosokawa K, Kubota Y, Hirashima M, Toyama H, *Suda T. Enhanced Angpt1/Tie2 signaling affects the differentiation and long-term repopulation ability of hematopoietic stem cells. Biochem Biophys Res Commun 2012. 430(1): 20-5, 2013. pubmed


  1. Nakamura-Ishizu A, Kurihara T, Okuno Y, Ozawa Y, Kishi K, Goda N, Tsubota K, Okano H, Suda T and *Kubota Y. The formation of an angiogenic astrocyte template is regulated by the neuroretina in a HIF-1-dependent manner. Dev Biol 363(1): 106-14, 2012. pubmed
  2. Sano K, Katsuta O, Shirae S, Kubota Y, Ema M, Suda T, Nakamura M and *Hirashima M. Flt1 and Flk1 mediate regulation of intraocular pressure and their double heterozygosity causes the buphthalmia in mice Biochem Biophys Res Commun 420(2): 422-7, 2012. pubmed
  3. Takase H, Matsumoto K, Yamadera R, Kubota Y, Otsu A, Suzuki R, Ishitobi H, Mochizuki H, Kojima T, Takano S, Uchida K, Takahashi S, and *Ema M. Genome-wide identification of endothelial cell-enriched genes in the mouse embryo Blood 120(4): 914-23. 2012. pubmed
  4. Nakamura-Ishizu A, Okuno Y, Omatsu Y, Okabe K, Morimoto J, Uede T, Nagasawa T, Suda T and *Kubota Y. Extracellular matrix protein Tenascin-C is required in the bone marrow microenvironment primed for hematopoietic regeneration. Blood 119(23): 5429-5437, 2012. pubmed
  5. Okuno Y, Nakamura-Ishizu A, Otsu K, Suda T and *Kubota Y. Pathological neoangiogenesis depends on oxidative stress regulation by ATM. Nat Med 18(8): 1208–1216, 2012. pubmed
    Nature Medicine Preview
    Cell Metabolism Preview
    Lifescience review (Japanese)
  6. *Kubota Y. Tumor angiogenesis and anti-angiogenic therapy. Keio J Med. 61(2): 47-56, 2012 (invited review). pubmed


  1. *Kubota Y, Takubo K, Hirashima M, Nagoshi N, Kishi K, Okuno Y, Nakamura-Ishizu A, Sano K, Murakami M, Ema M, Omatsu Y, Takahashi S, Nagasawa T, Shibuya M, Okano H and *Suda T. Isolation and function of mouse tissue resident vascular precursors marked by myelin protein zero. J Exp Med 208(5): 949-60, 2011. pubmed
  2. Okuno Y, Nakamura-Ishizu A, Kishi K, Suda T and *Kubota Y. Bone marrow-derived cells serve as pro-angiogenic macrophages but not endothelial cells in wound healing. Blood 117(19): 5264-72, 2011. pubmed
  3. Shimizu R, Okabe K, Kubota Y, Nakamura-Ishizu A, Nakajima H and *Kishi K. Sphere formation restores and confers hair-inducing capacity in cultured mesenchymal cells. Exp Dermatol 20(8): 679-81, 2011. pubmed
  4. *Kubota Y and Suda T. Vascularity of nongynecological leiomyosarcoma depends on colony-stimulating factor 1 but not on vascular endothelial growth factor. Am J Pathol 179(4): 1591-3, 2011. pubmed
  5. Zou P, Yoshihara H, Hosokawa K, Tai I, Shinmyozu K, Tsukahara F, Maru Y, Nakayama K, Nakayama KI, Suda T. p57(Kip2) and p27(Kip1) cooperate to maintain hematopoietic stem cell quiescence through interactions with Hsc70. Cell Stem Cell 9(3): 247-61 2011. pubmed


  1. Kurihara T, Kubota Y (equally first author), Ozawa Y, Takubo K, Noda K, Simon MC, Johnson RS, Suematsu M, Tsubota K, Ishida S, Goda N, *Suda T and *Okano H. von Hippel-Lindau protein regulates transition from fetal to adult circulatory system in retina. Development 137: 1563-1571, 2010. pubmed
  2. *Iwasaki H, Arai F, Kubota Y, Dahl M and *Suda T. Endothelial protein C receptor-expressing hematopoietic stem cells reside in the perisinusoidal niche in fetal liver. Blood 116(4): 544-53, 2010. pubmed
  3. *Takubo K, Goda N, Yamada W, Iriuchishima H, Ikeda E, Kubota Y, Shima H, Johnson RS, Hirao A, Suematsu M,* Suda T. Regulation of the HIF-1alpha Level Is Essential for Hematopoietic Stem Cells. Cell Stem Cell 7(3): 391-402, 2010. pubmed
  4. Nakada S, Tai I, Panier S, Al-Hakim A, Iemura S, Juang YC, O'Donnell L, Kumakubo A, Munro M, Sicheri F, Gingras AC, Natsume T, Suda T, Durocher D. Non-canonical inhibition of DNA damage-dependent ubiquitination by OTUB1. Nature 466(7309): 941-6, 2010. pubmed


  1. *Kubota Y, Takubo K, Shimizu T, Ohno H, Kishi K, Shibuya M, Saya H and *Suda T. M-CSF inhibition selectively targets pathological angiogenesis and lymphangiogenesis. J Exp Med 206: 1089-102, 2009. pubmed
  2. *Kubota Y and *Suda T. Feedback mechanism between blood vessels and astrocytes in retinal vascular development. Trends Cardiovasc Med 19: 38-43, 2009 (invited review). pubmed
  3. Morikawa S, Mabuchi Y, Kubota Y, Nagai Y, Niibe K, Hiratsu E, Suzuki S, Miyauchi-Hara C, Nagoshi N, Sunabori T, Shimmura S, Miyawaki A, Nakagawa T, Suda T, Okano H and *Matsuzaki Y. Prospective identification, isolation, and systemic transplantation of multipotent mesenchymal stem cells in murine bone marrow. J Exp Med 206: 2483-96, 2009. pubmed


  1. *Kubota Y, Hirashima M, Kishi K, Stewart CL and *Suda T. Leukemia inhibitory factor regulates microvessel density by modulating oxygen-dependent VEGF expression in mice. J Clin Invest 118(7): 2393-2403, 2008. pubmed
  2. Kubota Y, Takubo K and *Suda T. Bone marrow long label-retaining cells reside in the sinusoidal hypoxic niche. Biochem Biophys Res Commun 366: 335-9, 2008. pubmed
  3. Nagoshi N, Shibata S, Kubota Y, Nakamura M, Nagai Y, Satoh E, Morikawa S, Okada Y, Mabuchi Y, Katoh H, Okada S, Fukuda K, Suda T, Matsuzaki Y, Toyama Y, *Okano H. Ontogeny and Multipotency of Neural Crest-Derived Stem Cells in Bone Marrow, Dorsal Root Ganglia and Whisker Pad of Adult Rodents. Cell Stem Cell 2: 392-403, 2008. pubmed


  1. *Kaname T, Yanagi K, Chinen Y, Makita Y, Okamoto N, Maehara H, Owan I, Kanaya F, Kubota Y, Oike Y, Yamamoto T, Kurosawa K, Fukushima Y, Bohring A, Opitz JM, Yoshiura K, Niikawa N and Naritomi K. Mutations in CD96, a member of the immunoglobulin superfamily, cause a form of the C (Opitz Trigonocephaly) syndrome. Am J Hum Genet 81(4): 835-41, 2007.
  2. Morita K, *Miyamoto T, Fujita N, Kubota Y, Ito K, Takubo K, Miyamoto K, Ninomiya K, Suzuki T, Iwasaki R, Yagi M, Takaishi H, Toyama Y and *Suda T.  Reactive oxygen species induce chondrocyte hypertrophy in endochondral ossification. J Exp Med 204(7): 1613-23, 2007. pubmed